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Since the "Desperate Housewives" finale aired last May, Marcia Cross has stayed mostly low-key. But when she was asked to participate in a PSA to promote prostate cancer awareness, she says it was a "no-brainer" because her close friend's husband had been diagnosed with the disease.

"There are so many causes out there but when someone you know is affected by it, it becomes more personal," Cross, 51, who also advocated for breast cancer awareness after her friend - the same friend whose husband was sick - learned she had the disease, tells ABC News.

"It's so selfish that I get to do something so simple and I get to feel like I've done something."

For Cross, who has partnered with Safeway Foundation and Stand Up to Cancer (SU2C), cancer has been an all-too-familiar presence. Not only have her friends been diagnosed with the disease, but her longtime companion, Richard Jordan, died of brain cancer in 1993, and her husband, stockbroker

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Even for those who don't lose a loved one after a tornado, the process to rebuild is "long" and "emotional," according to Tammy Cady, 59, who survived the tornado that hit Joplin, Mo. on May 22, 2011.

Since the “Desperate Housewives” finale aired last May, Marcia Cross has stayed mostly low-key. But when she was asked to participate in a PSA to promote prostate cancer awareness, she says it was a “no-brainer” because her close friend’s husband had been diagnosed with the...