Exposure to Toxic Solvents Linked to Parkinson's Disease

MONDAY, Nov. 14 (HealthDay News) -- Exposure to the industrial solvent trichloroethylene (TCE) appears to greatly increase the risk of Parkinson's disease, and exposure to two other solvents also boosts the chances of developing the neurodegenerative disorder, a new study indicates.

As many as 500,000 people in the United States have Parkinson's disease and more than 50,000 new cases are diagnosed in the country each year. Some research suggests that genetic and environmental factors might trigger Parkinson's, and several studies have reported that exposure to solvents may increase the risk.

In this new study, U.S. researchers interviewed 99 pairs of elderly twins about their lifetime occupations and hobbies. Exposure to TCE was associated with a sixfold increased risk of Parkinson's disease. Exposure to perchloroethylene (PERC) and carbon tetrachloride (CCI4) were also associated with increased risk.

The study was led by researchers at The Parkinson's Institute in Sunnyvale, Calif., and was published Nov. 14 in the journal Annals of Neurology.

"Our findings, as well as prior case reports, suggest a lag time of up to 40 years between TCE exposure and onset of [Parkinson's], providing a critical window of opportunity to potentially slow the disease process before clinical symptoms appear," said Dr. Samuel Goldman and colleagues in a journal news release.

While this study focused on job-related exposure, the solvents are common in soil, groundwater and the air in the United States. For example, TCE is detected in up to 30 percent of the nation's drinking water supplies, according to the researchers.

"Our study confirms that common environmental contaminants may increase the risk of developing [Parkinson's], which has considerable public health implications," Goldman and colleagues said.

All three solvents linked to Parkinson's are used extensively worldwide and TCE is a common agent in paints, adhesives, carpet cleaners and dry-cleaning solutions. In the United States, millions of pounds of TCE are released into the environment each year.

More information

We Move has more about Parkinson's disease.

 
  • David  •  6 months ago
    Diethylenetriamine . . . blew the whistle on a former employer sloshing 5 gallon buckets of this stuff on the floor in a semiconductor factory. Coworkers were having problems breathing, eyes were red, I was the only one out of 300 employees to ask what that stuff was. They resisted telling me for 3 days until I threatened to call OSHA again. Called me a troublemaker, too.
    Turns out this stuff is pretty toxic. I calculated that it was safe to have only 11 ounces of this stuff evaporated into the air in the building (it was 180 feet x 360 feet x 60 feet), and they had guys slathering a floor coating in the basement that was 50% this stuff (a solvent) and they had multiple 5-gallon buckets of this stuff applied to the floor.
    --- So I told my supervisor about this (he couldn't have cared less) and his boss (who couldn't care less) and his boss (who couldn't care less) and his boss (who couldn't care less) and then I called OSHA.
    Yeah, I like semiconductors, but the factories that make them use lots of awful chemicals, and safety is so far down the list of concerns, it's terrible . . .
    One lady told me she had lung problems, had to get a biopsy done, and she was afraid to ask for a list of the chemicals she worked with. The company is supposed to post all that stuff, but they didn't. So on my breaks, I got the information for her. The next week, they got her an office job, away from the chemicals.

    Yeah, we need more support from the EPA and OSHA. Not less.
    • JungleBoogieMonster 6 months ago
      If we start reporting dangerous working conditions the companies will just lobby the government to drop the laws protecting us.
    • ChristianStacey 5 months ago
      No, the EPA and OSHA need to be abolished. What we need is what Ron Paul calls "Contract Law", where Employees can use common law, to sue Employers and win for damages to your health. Today, that process is impossible, and by law its limited to how much you can "win". Employees need their individual rights back, not more regulations. Today, Employers are not afraid of their Employees whatsoever. Per the above example.
    • Blanco POV 5 months ago
      When companies don't pay their fair share of taxes ,then the watch dog government agencies don't have the budget to send people to do any inspections.
  • happylady  •  6 months ago
    My mother died of Parkinson's disease on May 2, 2011. Watching a vibrant woman wither away to nothing was horrible !!! Anything that can be done to figure out what contributes to this evil disease is necessary.
    • Groucho Marxist 6 months ago
      I'm sorry about your mom. My pop went in '03 and the pain still lingers. It's as you described, Parkinson's literally whittled him down to nothing. I'll add a prayer for you tonight. Take care.
    • BrownCoat Veteran 5 months ago
      .. sorry for your loss.. I'm "caregiver" to my mom & her brother, both with Parkinson's, & unk also has Dementia.. Not to mention the way they feel, the loss of mobility, pride, self esteem.. it truly is the worst thing I've ever had to do, to watch them both just.. rot away.. there's not much I can do to stop it..
    • D 5 months ago
      As a child I grew up naive, believing we were safe because our government looked out for us. I believed in the USDA, FDA, EPA, etc. I did not understand that in order for me to have a plastic bag to carry my groceries in that it required a long series of industrial processes that produced waste toxins that got dumped into our environment. These toxins, in most cases, do not break down so it's a cumulative effect on the water, air and soil over time. It's only going to get worse and worse. The trust is our government is not looking out for the best interest of the people or the country over the course of generations but rather what is best for those in office at that time.

      When are we going to all care about ourselves, our grandchildren, their grandchildren and the environment we have to live in more than our dry cleaning?
  • allen  •  5 months ago
    Sounds like A Class Action lawsuit to me!!!!!
    • Ed 5 months ago
      And with a mesothelioma structured trust fund for the victims; as result.
  • Scott  •  5 months ago
    I have used many harsh chemicals and compounds in the construction, electrical and automotive industries TCE, PCB's, Mercury, lead and others.I used to use my bare hands with no dust mask to mix Asbestos with cement over a 5 gallon bucket to make chimney cement, I think at the time I made $3.00 /Hr. The real irony is this whole time marijuana was and is still illegal #$%$ ????
  • todd  •  6 months ago
    Yikes! When I was 15 working under a state work permit I spent a summer with a five gallon bucket of this crap cleaning thread cutting oil off pipe fittings. Only after having become violently sick to my stomach was I offered gloves. Even then, my skin peeled for weeks and I could taste this crap in my breath. I suffer "fasciculations" but have been told they are related to spinal cord injuries and multiple spinal fusions...Oh well. I was more worried about asbestos since the same employer used to have me cutting sheets of it with a circular saw...maybe I AM a medical miracle (so told for not being paralyzed from my broken neck) like they said?
  • WATCHEM  •  San Diego, United States  •  6 months ago
    Carbontet was a common open basin cleaning solvent in aircraft instrument repair shops.
    • FRANK S 6 months ago
      We used it for cleaning the fittings on the cabin oxygen lines in planes. Nasty stuff. It was even mentioned in the TV show "Lost in Space" in one episode.
    • JessM 6 months ago
      Carbon Tet was also used in the dry cleaning industry and has been banned for years.
    • coyote kid 6 months ago
      back in 1957 i worked in a materials testing lab with the corps of engineers. we used carbon tet to clean equipment used in the testing of asphalt paving materials. i handled this solvent without the benefit of gloves or masks. i wonder............
  • s  •  6 months ago
    EFAs (Essential Fatty Acids) help recoat the myelin sheath that surrounds nerve fibers. Milk thistle tabs clear the liver of excess toxins (even Dr. Oz touts). Google "myelin support oils" for more info. Many links with great info. They really help. Even for the very young whose nervous systems seem "raw", when always overstimulated and twitchy.
    • Gordon 5 months ago
      This is either not relevant to a discussion about Toxic Solvents, or it purports some remedy? In either case, maybe your focus is too narrow? I think. Please relate your posting to something that most people will, hopefully, understand. Or are you just trying to sound smart for an ego gratification? Hopefully, not.
    • Jen~ 5 months ago
      They are giving some info on how to manage the symptoms. EFAs are so beneficial for many reasons. Their help in supporting the nervous system could probably really help those diagnosed with Parkinson's.
    • tony 5 months ago
      BR549 is not very bright. Too much solvent already? Maybe they will some day look up what a myelin sheath is/does and how it relates to CNS diseases.
  • ocliffgirl  •  Dallas, United States  •  6 months ago
    My mother had 2 brothers and 2 sisters. Only she and 1 brother had Parkinson's. My mother was a beauty operator (lots of exposure to chemicals there) and my uncle worked for the Texas Highway Department as an engineer, so he was out in the field a lot. He always said he and my mother got sick because of chemical exposure. They both died in 2006, just months apart.
  • Ned Neederlander  •  5 months ago
    Many, many assembly line workers, including myself while working for Delco Electronics in Kokomo Indiana during the 70's were exposed to trichloroethylene while manufacturing transistors and printed circuit boards.
  • toadster  •  Los Angeles, United States  •  6 months ago
    I hate to think of everything I've been exposed to in the past 65 years but it is hard to live a life with out interacting with chemicals. I do try to be more careful these days although it maybe too late.
  • NotThisUHaul  •  5 months ago
    I've been working around this stuff for 70+ years. Having read this story, I'm afraid of how these chemicals may affect my health in the coming decades!
  • Sacagawea  •  6 months ago
    Just looked up TCE. Yikes. It's been pumped into the environment for some time now. This makes me sad.
  • Snoopy  •  6 months ago
    The stuff works great but you really know deep down that it is not good for you (or the environment) to be exposed to. Not at all surprised at the link between TCE and Parkinson's.
  • guts  •  6 months ago
    where screwed again!
  • William  •  6 months ago
    TCE, PERC, and carbon tet are all regulated in the environment. When standards are exceeded, remedial measures are necessary. These chemicals are toxic, and environmental exposure is not acceptable. But then we're told by corporate apologists that regulations are the problem, not the contamination itself.
  • ewking53  •  Kansas City, United States  •  6 months ago
    I work for a defense contractor and we used to use TCE or Trico for many years to clean printed wiring boards. We quit using it about 20 yrs. ago I have used many chemicals over my 30 year career and will have to compile a list for my wife before I die. I know a coworker with Parkinsons. Will have to tell his wife about this article.
  • David  •  5 months ago
    This stuff also causes death if you drink it
  • BushLizard2U  •  5 months ago
    You really think your Boss gives a Hoot .... get back to work peons.
  • Groucho Marxist  •  Guangzhou, China  •  6 months ago
    In the 80's medical researchers were also finding correlations with DDT exposure. What I'm really hoping for is a cure, as I lost my pop to Parkinson's and don't want to see any more people go through that.
  • Anonymous  •  6 months ago
    All the more reason to eliminate the EPA! How DARE peoples health take precedent over corporate profits!

    /end sarcasm/